In a study involving 4,162 young adult subjects between the ages of 18 and 30 years, with a history of asthma at baseline, who were followed up with for 20 years, during which time 446 incident cases of asthma were identified, long-chain omega-3 polyunsaturated fatty acid intake was found to be significantly inversely associated with incidence of asthma. Comparing the highest to the lowest quintiles of omega-3 fatty acid intake, the multivariable HR was 0.46. A greater inverse association was found for DHA as compared to EPA, and nonfried fish consumption was not associated with risk. The authors conclude, "This study showed that intakes of LC[omega]3PUFAs are inversely longitudinally associated with the incidence of asthma in American young adults.
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