Boswellia serrata has been traditionally used in India and other countries since ancient times with minimum side effects for the treatment of several diseases including inflammatory disorders and cancer. The active constituents of the extract, namely boswellic acids, were shown to inhibit 5-lipoxygenase and human leukocyte elastase, and were shown to be direct, non-redox inhibitors of mammalian 5-lipoxygenase. In experimental animal models, boswellic acids have been shown to be beneficial in Crohn's disease, ulcerative colitis and ileitis. Boswellia extract also showed inhibitory action on topoisomerase I and II, in vitro. The extract also induced caspase activation-dependent apoptosis in various cancer cell lines. In a recent study, a highly absorbable boswellia extract, up to five times more absorbable than regular boswellia, was found to be approximately three times more effective than Camptothecin, a drug usually prescribed in colorectal cancer cases that are refractory to standard chemotherapy treatment. Boswellic acids were reported to increase intracellular calcium and activity of mitogen activated protein kinase (MAPK) in human isolated leukocytes. Boswellia has been studied and shown significant benefits for effectively treating COPD, asthma, emphysema, bronchitis and sinusitis. Because of its inhibition of the 5-Lox enzyme, it can reduce the thickening of the arteries by up to 50%. Useful as a very powerful anti-inflammatory, it has been clinically shown to reduce the symptoms of rheumatoid arthritis. Because of its effect on the 5-Lox enzyme, it can successfully treat over 60 diseases. I have written an article on “Nutritional Support for Inflammatory Intestinal, Bowel Disorder and Upper Respiratory Tract” which you can read on my website. Just search on my website for boswellia. It has been used for thousands of years in Ayurvedic medicine and has little or minimal side effects.
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