Vitamin D Status in Patients with Crohn's Disease
In a pilot study involving 18 patients with mild-to-moderate Crohn's disease (150-400 CDAI scores), 24 weeks of supplementation with 5000 IU/d vitamin D3 was effective in raising 25(OH)D3 levels in this study population. For a period of 2 weeks, vitamin D3 oral supplementation was started at 1000 IU/d, and after 2 weeks this was incrementally increased until patients' serum concentrations reached 40 ng/mL or they were taking 5000 IU/d. Of the 18 patients, 14 required 5000 IU/d to achieve vitamin D levels above 40 ng/mL. The authors conclude, "Twenty-four weeks supplementation with up to 5,000 IU/d vitamin D3 effectively raised serum 25(OH)D3 and reduced CDAI scores in a small cohort of Crohn's patients suggesting that restoration of normal vitamin D serum levels may be useful in the management of patients with mild-moderate Crohn's disease.