While vaccines are currently in the works and are starting to be distributed, there is still a long road ahead in the fight against Covid-19. One constant factor that has come to the forefront during this time is the importance of nutrients in strengthening and moderating the body’s responses to viruses.
Nutrients including vitamins A, C, D, and E plus selenium and zinc protect respiratory cell structures to help them resist viruses, moderate cytokine levels in the event of an infection, and reduce inflammation throughout the body.
Other nutrients, including curcumin, propolis, quercetin, and a variety of botanical polyphenols also stop inflammatory reactions, prevent the attachment of viruses to cells, and inhibit the oxidative damage caused by viruses, helping the body maintain a baseline of immune strength.
An important aspect to any nutrient regimen is ensuring that you get absorbable, effective supplement sources. Look for formulas with bioavailable minerals, curcumin enhanced with turmeric essential oil, and other botanicals that are verified for their authenticity and, ideally, clinically and scientifically validated.
Keflie TS, Biesalski HK. Micronutrients and Bioactive Substances: Their Potential Roles in Combating COVID-19. Nutrition. 2020; 111103. ISSN 0899-9007, https://doi.org/10.1016/j.nut.2020.111103.
Objective: COVID-19 pandemic has been seriously threatening public health and setting huge economic crises across the world. In absence of specific drugs to COVID-19, there is an urgent need to look for alternative approaches. Therefore, the aim of this paper was to review the roles of micronutrients and bioactive substances as potential alternative approaches in combating COVID-19.
Methods: This review was based on literature identified using electronic searches in different databases.
Results: Vitamins (A, B, C, D and E), minerals (selenium and zinc) and bioactive substances from curcumin, echinacea, propolis, garlic, soybean, green tea, and other polyphenols were identified for having potential roles in interfering with spike glycoproteins, angiotensin converting enzyme 2 and transmembrane protease serine 2 (TMPRSS2) at the entry site; and inhibiting activities of Papain-Like protease (PLpro), 3 Chymotrypsin-Like protease (3CLpro) and RNA dependent RNA polymerase (RdRp) in the replication cycle of SARS-CoV-2. Having immuno-modulating, anti-inflammatory, antioxidant and antiviral properties, such micronutrients and bioactive substances are consequently the promising alterative nutritional approaches to combat COVID-19.
Conclusion: To put in nutshell, the roles of micronutrients and bioactive substances in COVID-19 are exciting research areas and thus, this review may guide researchers to undertake further studies.
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