Study Spotlight

Study Spotlight

Resveratrol May Improve Insulin Sensitivity in Older Adults with Impaired Glucose Tolerance


In this 4-week, open-label study, the authors investigated the ability of resveratrol to influence glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT). Subjects (n=10) (72 +/- 3 yrs) (M +/- SD) with IGT were enrolled. Participants received resveratrol (daily dose 1, 1.5, or 2 g) following a standard mixed meal (110 g carbohydrate, 20 g protein, 20 g fat). 3-hour glucose and insulin area under the curve (AUC), insulin sensitivity (Matsuda index), and secretion (corrected insulin response at 30 minutes) were measured. Results did not differ by dose. At baseline, body mass index was 29 +/- 5 kg/m(2), fasting plasma glucose 110 +/- 13 mg/dL, and 2-hour glucose 183 +/- 33 mg/dL. At end of study, fasting plasma glucose was unchanged, but peak post-meal (185 +/- 10 vs 166 +/- 9 mg/dL, p = .003) and 3-hour glucose AUC (469 +/- 23 vs 428 +/- 19, p = .001) declined. Matsuda index improved (3.1 +/- 0.5 vs 3.8 +/- 0.5, p = .03), and corrected insulin response at 30 minutes was unchanged (0.6 +/- 0.1 vs 0.5 +/- 0.5, p = .49). Researchers found resveratrol at 1 or 2 g per day may improve insulin sensitivity and post-meal plasma glucose in subjects with IGT.

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