Red Clover Isoflavones in Postmenopausal Women: Skin, Appendages, Mucosal Status
In a crossover, placebo-controlled study involving 109 postmenopausal women, supplementation with red clover extract isoflavones was found to improve scalp hair and skin status, libido, mood, sleep, and reduce tiredness. Subjects were randomized to: 2 daily capsules of the red clover extract (80 mg), or placebo, for a period of 90 days, after which the interventions were crossed over (after a 7 day washout period). Subjective improvements in scalp hair and skin status, libido, mood, sleep, and tiredness were found after supplementation with red clover extract. No significant differences in urinary complaints, nail, body hair, and oral/nasal/ocular mucosa were found. Subjects in the red clover extract group reported higher overall satisfaction. The authors conclude, "RCE supplementation exerted a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women."