Red Clover Isoflavones and Vasomotor Symptoms in Postmenopausal Women
In a placebo-controlled study involving 109 postmenopausal women aged 40 years or older, supplementation with red clover isoflavones (80 mg/d) for a period of 90 days, was found to be associated with reducing daily hot flashes and vasomotor symptoms and overall intensity of menopausal symptoms. Specifically, subjects were randomized to 80 mg/d red clover isoflavones or placebo for a period of 90 days, after which the interventions were crossed over (following a 7 day washout). Supplementation with red clover isoflavones was associated with significant reductions in daily hot flashes, night sweats, and overall menopausal symptom intensity, while placebo was associated with increases in all indices. The authors state, "Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women."