Low Vitamin D Status Linked to Increased Risk of Type 2 Diabetes
In a study involving 9,841 subjects from the general population, out of which 810 developed type 2 diabetes during 29 years of follow up, lower 25(OH)D concentrations, were found to be associated with higher cumulative incidence of type 2 diabetes (multivariable adjusted HRs were: 1.22 for 25(OH)D less than 5 microg/dL vs 20 microg/L or greater; 1.35 for the lowest vs the highest quartile; and 1.12 for 50% lower concentration of 25(OH)D). The OR of type 2 diabetes was 1.50 for the bottom vs the top quartile of 25(OH)D according to a meta-analysis of 16 studies. The authors conclude, "We observed an association of low plasma 25(OH)D with increased risk of type 2 diabetes. This finding was substantiated in a meta-analysis.