Low Serum Vitamin D Linked to Increased Risk of Diabetes Mellitus in Korean Adults
In a large, population-based survey study involving cross-sectional analyses carried out on data collected from 5,787 Korean adults (2543 men and 3334 women), low serum 25(OH)D concentrations were associated with an increased risk of diabetes mellitus. Diabetes mellitus was defined as having a fasting plasma glucose of 7 mmol/L or greater or currently using oral hypoglycemic agents or insulin. As compared to subjects with sufficient vitamin D status (25(OH)D of 75 nmol/L or greater), those with serum 25(OH)D concentrations less than 25, 25 to <50, and 50 to <75 nmol/L were found to have ORs for diabetes mellitus of: 1.73, 1.30, and 1.40. In addition, serum 25(OH)D was inversely associated with HOMA-IR and positively associated with QUICKI in overweight or obese subjects. The authors conclude "a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resist ance in those who are overweight or obese."
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