Low Intestinal Microbial Diversity in Infants May Correlate with Atopic Eczema
Researchers examined the relationship between intestinal microbial diversity and development of atopic eczema in the first year of life. Subjects were infants (n=40) with IgE-associated eczema (n=20) (IAE) and without any allergic manifestation (n=20) (NA) until 2 years of age. Microbial diversity and composition were analyzed through stool samples at 1 week, 1 month, and 12 months of age. Authors found IAE had a lower diversity of the total microbiota at 1 month and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P = .02 and P = .01) and the phylum Proteobacteria at 12 months of age (P = .02). The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability. At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in NA group. Findings suggest that low intestinal microbial diversity during the first month of life may be as sociated with subsequent atopic eczema.
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