Study Spotlight

Study Spotlight

L-Carnitine in the Secondary Prevention of Cardiovascular Disease


In a systematic review and meta-analysis of 13 controlled trials (n=3629), supplementation with L-carnitine was found to be associated with a significant 27% reduction in all-cause mortality (OR=0.73), a highly significant 65% reduction in ventricular arrhythmias (RR=0.35), and a significant 40% reduction in the development of angina (RR=0.60), with no significant reduction in the development of heart failure (RR=0.85) or myocardial infarction (RR=0.78). The authors conclude that as compared to placebo or a control, L-carnitine may offer benefits in terms of reducing all-cause mortality, ventricular arrhythmias, and anginal symptoms in patients with acute myocardial infarction. "Further study with large randomized controlled trials of this inexpensive and safe therapy in the modern era is warranted."

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