Study Spotlight

Study Spotlight

Homocysteine May Be A Risk Factor for Lower Physical Performance in the Elderly


Researchers examined whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance in this cross-sectional and longitudinal study. Subjects were 65 yrs or older. Blood was collected in 1995/1996 (n=1352). Physical performance was assessed in 1995/1996 and in 1998/1999. Study found that women in the highest quartile of homocysteine had a significantly lower physical performance than did those in the lowest quartile in the cross-sectional analyses. No statistically significant associations with physical performance were found for vitamin B12 in women or vitamin B12 or homocysteine in men. Researchers conclude that high plasma homocysteine may be an independent risk factor for lower physical performance in older women.

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