Study Spotlight

Study Spotlight

Grapes are Great for Memory


As we age, inflammation and oxidative stress can make it difficult for signals in the brain to connect clearly. The result can be the often-cited search for car keys, an acquaintance’s forgotten birthday, or difficulty remembering where you’ve parked.

But the solution may be as close as your grocery store.

A clinical study with older adults who had mild cognitive impairment found that after 12 weeks of supplementing with Concord grape juice, their verbal learning ability improved significantly. To a lesser extent, the grape juice seemed to help spatial and non-verbal recall as well.

Just note that before you pick up a big bottle of Concord grape juice that there was a slight increase in fasting insulin levels, so it’s something to keep in mind if you’re sensitive to additional sugars in your diet. Most likely though, the increasing attention to Concord grape juice and grape juice powder will prompt more supplemental research for replicable results.

Abstract:

Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010 Mar;103(5):730-4.

Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signaling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have indicated improvement in memory and motor function with grape juice supplementation, suggesting potential for cognitive benefit in ageing humans. In this initial investigation of neurocognitive effects, we enrolled twelve older adults with memory decline but not dementia in a randomized, placebo-controlled, double-blind trial with Concord grape juice supplementation for 12 weeks. We observed significant improvement in a measure of verbal learning and non-significant enhancement of verbal and spatial recall. There was no appreciable effect of the intervention on depressive symptoms and no effect on weight or waist circumference. A small increase in fasting insulin was observed for those consuming grape juice. These preliminary findings suggest that supplementation with Concord grape juice may enhance cognitive function for older adults with early memory decline and establish a basis for more comprehensive investigations to evaluate potential benefit and assess mechanisms of action.

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