Study Spotlight

Study Spotlight

Grape seed proanthocyanidins and metformin act by different mechanisms...


Grape seed proanthocyanidins and metformin act by different mechanisms to promote insulin signaling in rats fed high calorie diet.

Oral administration of GSP improves hepatic insulin signaling and glucose metabolism in a diet-induced model of obesity by reducing the proinflammatory cytokine production and inhibiting the inflammatory pathways independent of AMPK activation. The standard drug MET activated AMPK and promoted insulin signaling. The effects of GSP in liver are more pronounced in combination with MET. This study suggests a potential role for GSP as a combination drug along with MET in patients with insulin resistance and T2D.

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