Fish Oil and Exercise May Reduce Insulin Resistance in Viscerally Obese Men
The effects of fish oil, exercise and fish oil and exercise in combination on fasting and postprandial chylomicron metabolism were tested in this single blind study. Men (n=29) with metabolic syndrome were randomly assigned to take fish oil or placebo for 4 wks, prior to an additional 12 wk walking program. Subjects were tested for concentrations of fasting apo B48, plasma lipids and insulin at baseline and post-treatment. Postprandial apo B48 and TAG kinetics were determined following ingestion of a fat enriched meal. Researchers found that combining fish oil and exercise resulted in a significant reduction in the fasting apo B48 concentration, concomitant with attenuation of the fasting TAG concentration and postprandial TAGIAUC response. Fish oil alone reduced the postprandial TAG response but not postprandial apo B48 kinetics. Findings suggest that fish oil may independently improve plasma TAG homeostasis but not resolve hyper-chylomicronaemia, that fish oil in combin ation with chronic exercise may reduce the plasma concentration of pro-atherogenic chylomicron remnants and reduce the fasting and postprandial TAG response in viscerally obese insulin resistant men.