Elevated Homocysteine Linked to Lower Cognitive Impairment Scores
In a study involving 288 right-handed participants aged 55 years and older, elevated homocysteine levels were found to be associated with reduced global cerebral volume, larger ventricles, reduced cerebral white matter volume, and lower cognitive performance in several domains. Specifically, elevated homocysteine levels were associated with reduced white matter volume and lower speed of processing. The authors state, "In non demented, relatively healthy adults, elevated homocysteine is associated with lower cognitive scores and reduced cerebral white matter volume. These effects can be dissociated from those related to white matter hyperintensities or reduced folate level."