Does Curcumin Hold a Key for Anti-Aging?

Most people would say that they would like to live longer, but also remain healthy. That ideal situation could be called the fusion of lifespan and healthspan.

One of the reasons that cells age at all is a process called cellular senescence. There’s a lot that contributes to the aging of cells, and as a result, our minds and bodies: inflammation caused by the environment, diet, our genes, or any combination of those factors.

Additionally, senescent cells create low grade inflammation, so the very thing that can be caused by inflammation is also causing additional inflammation in return. It all adds up to one thing: accelerated aging.

One way to circumvent aging cells is through caloric restriction. This study reported that Okinawans are noted for five times more centenarians (people over 100 years old) on their island than any other place in the world. One of the reasons cited for this is the fact that Okinawans consume 17 percent fewer calories than the average adult in Japan and 40 percent fewer than the average American.

Caloric restriction appears to boost the activity of sirtuins, proteins that are involved with metabolism, cellular stresses, and aging. But however beneficial caloric restriction might be, it isn’t for everyone. Fortunately, there is another way of helping cells throughout the body and mind stay youthful and prevent the inflammatory and oxidative aspects of aging and disease. It is the key compound from turmeric – curcumin.

Curcumin from turmeric (Curcuma longa) has long been noted for its anti-inflammatory and antioxidant abilities, traits that already make it a valuable ally in the fight against cellular damage and aging.

What the authors of this study found was that curcumin also boosted sirtuin activity, much like the effects of caloric restriction.

One of the challenges of curcumin supplementation is that the compound can be difficult to absorb from plain turmeric or even just plain standardized curcumin. However, one clinically studied form of curcumin blends the compound with turmeric essential oil, enhancing absorption and blood retention time, while also providing additional benefits associated with the oil.

While there’s no substitute for a healthy diet and exercise for a natural way to stay younger, curcumin is a simple addition to a daily regimen. It provides a multitude of side benefits that strongly support a path toward optimal health and longevity.

Abstract:

Bielak-Zmijewska A, Grabowska W, Ciolko A, et al. The Role of Curcumin in the Modulation of Ageing. Int J Mol Sci. 2019;20(5):1239. Published 2019 Mar 12. doi:10.3390/ijms20051239

It is believed that postponing ageing is more effective and less expensive than the treatment of particular age-related diseases. Compounds which could delay symptoms of ageing, especially natural products present in a daily diet, are intensively studied. One of them is curcumin. It causes the elongation of the lifespan of model organisms, alleviates ageing symptoms and postpones the progression of age-related diseases in which cellular senescence is directly involved. It has been demonstrated that the elimination of senescent cells significantly improves the quality of life of mice. There is a continuous search for compounds, named senolytic drugs, that selectively eliminate senescent cells from organisms. In this paper, we endeavor to review the current knowledge about the anti-ageing role of curcumin and discuss its senolytic potential.

Here is the link to the complete article: The Role of Curcumin in the Modulation of Ageing

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