It’s easy to connect inflammation with specific physical symptoms, like joint pain, flare ups with digestives disorders, or sinus congestion. But systemic inflammation – not just reflected in the things you feel immediately, but in the very workings of the body, can negatively impact the immune system and its ability to respond, too.
Fortunately, and maybe not surprisingly, an inflammation-fighting compound could be used in the frontline of immune defense. Curcumin from turmeric can mitigate inflammation throughout the body during times of illness and in the lead-up to bacterial or viral infections.
A review cataloged some of inflammatory pathways that curcumin modulates and found that while many of them are implicated in tumor formation and growth, these same inflammatory markers may have an influence on the severity of acute conditions, including colds and flus.
The ability of curcumin to inhibit common markers of inflammation show that this botanical may be a powerful, if unexpected, line of immune defense. When adding curcumin to your regimen, selecting a supplement form that combines curcumin with turmeric essential oil for enhanced bioavailability, can ensure that it is most effective for keeping inflammation at bay and helping you maintain optimal health year-round.
Kahkhaie KR, Mirhosseini A, Aliabadi A, et al. Curcumin: a modulator of inflammatory signaling pathways in the immune system [published correction appears in Inflammopharmacology. 2019 Aug 19;:]. Inflammopharmacology. 2019;27(5):885-900
Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.
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