Curcumin May Alleviate Effects of Alcoholic Neuropathy in Rats
Researchers investigated the effect of curcumin (20, 40 and 80mg/kg; p.o.) in alcohol-induced neuropathy in rats. Ethanol (35% v/v, 10g/kg; p.o.) was administered for 10 weeks, significantly decreasing thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia and nerve conduction velocity and causing enhanced malondialdehyde, oxidative-nitrosative stress, total calcium levels, inflammatory mediators (TNF-a and IL-1b levels) along with DNA damage. Co-administration of curcumin and a-tocopherol for 10 wks improved nerve functions, biochemical as well as molecular parameters and DNA damage in sciatic nerve of ethanol treated rats. Curcumin may inhibit pro-inflammatory mediators like TNF-a and IL-1b and be of potent therapeutic value in the amelioration of alcoholic neuropathy in rats.
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