Curcumin as Possible Anti-Tumor Agent in Prostate Cancer
In a cell culture study, curcumin (active agent found in the popular yellow-colored curry spice, turmeric) was found to suppress the coactivator protein p300 (which are elevated in development and progression of prostate cancer) and CBP occupancy at sites of androgen receptor function, suggesting that curcumin may help in the prevention and possible treatment of prostate cancer. One of the emphases in the field of researchers looking to find ways of preventing and treating prostate cancer is to identify mechanisms by which castrate-resistant AR activity and pioneer factor function are combinatorially suppressed. The results of this cell study show that curcumin may have a beneficial effect in this regard. The authors conclude, "...our results demonstrate the combinatorial impact of targeting AR and histone modification in prostate cancer, setting the stage for further development of curcumin as a novel agent to target AR signaling."