Correlation of Nutrient Biomarkers and Cognitive Function in the Elderly
Study authors examined the cross-sectional relationship between nutrient status (30 plasma biomarkers of diet) and indices of brain health (cognitive and MRI outcomes) in dementia-free elders (mean age=87, 62% female). Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine omega-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine omega-3 pattern and white matter hyperintensity volume. Researchers report distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume.
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