Correlation Found Between Lowered Serum levels of Antioxidants in Patients with Lichen Planus.
Lower serum levels of vitamin C in patients with lichen planus (LP) may contribute to increased levels of free radicals, resulting in increasing oxidative damage. In this study, 30 patients with LP, who had never received treatment for their disease, and 30 healthy subjects were recruited as the control group, were compared in terms of serum levels of antioxidants. Serum levels of glutathione peroxidase (GPX), vitamin C, selenium, bilirubin and uric acid were determined. All subjects were middle-aged (average 41 years of age). Subjects from the LP group demonstrated mean plasma levels of vitamin C that were significantly lower (P < 0.001) when compared with controls, indicating that free radicals and the resulting oxidative damage may be important in the pathogenesis of LP lesions. The effects of supplementation with vitamin C in such a population remains to be examined.
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