Combined Nutraceutical Treatment May Reduce Cholesterol and Improve Lipid Profile in the Elderly
In a prospective, randomized, parallel group, single-blind study involving 80 elderly subjects over the age of 75 years, with hypercholesterolemia, who were statin-intolerant and who refused other medications for the treatment of hypercholesterolemia, supplementation with a combination of nutraceuticals (berberine 500 mg, policosanol 10 mg, red yeast rice 200 mg, folic acid 0.2 mg, coenzyme Q10 2.0 mg, astaxanthin 0.5 mg) for periods of 3, 6, and 12 months was found to be associated with a statistically significant reduction in total cholesterolemia (-20%), LDL cholesterol (-31%), and insulin resistance (-10%), as compared with a placebo. The authors conclude, "...combined nutraceuticals significantly reduce cholesterolemia and achieved acceptable plasma LDL-C levels in elderly hypercholesterolemic patients who were previously statin-intolerant. Combined nutraceuticals is also safe and well tolerated in these patients."
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