Coenzyme Q10 Protects Against Acute Liver Injury Induced by Acetaminophen
In a study involving rats induced with liver injury through a single dose of acetaminophen (700 mg/kg, p.o.), administration with coenzyme Q10 (20 i.p. injections, 10 mg/kg each) at 1 and 12 hours following acetaminophen administration, was found to significantly reduce the levels of serum aminotransferases, suppress lipid peroxidation, prevent the decrease of reduced glutathione and catalase activity, decrease the elevation of TNF-alpha and nitric oxide, and attenuate the reductions of selenium and zinc ions in liver tissue resulting from acetaminophen administration. Furthermore, histopathological liver tissue damage resulting from acetaminophen was mediated by coenzyme Q10. The authors conclude that, "coenzyme Q10 protects rat liver against acute acetaminophen hepatotoxicity, most probably through its antioxidant, anti-inflammatory and antiapoptotic effects."
Click Here to visit the journal website. Subscription required to view the full text of the article.