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Can Curcumin Cure Metabolic Syndrome?

If you could mix together some of the most dangerous health conditions including, high blood pressure, rising cholesterol and triglyceride levels, insulin resistance, and abdominal weight gain, you’d get one of the most prevalent states of disease today: metabolic syndrome.

Metabolic syndrome affects at least 20 percent of the world’s population, and while it has many primary causes, including sedentary lifestyles, overconsumption of refined foods, family histories, and genetic predispositions, there is one condition lurking in the background: inflammation.

The authors of this review noted that curcumin, the frequently studied and highly regarded compound from turmeric (Curcuma longa) may help. Curcumin has a long track record in traditional medicine and is currently used in clinical research for everything from arthritis and joint pain to Alzheimer’s and depression. In general, these studies find good reason to recommend curcumin – low instances of side effects and inflammation-inhibiting activity along a multitude of pathways in the body.

Overall, curcumin supplementation was associated with significant reductions in weight, body mass index (BMI), and waist circumference, and a boost in adiponectin levels, a naturally occurring peptide that helps the body fight heart disease, obesity, and high blood sugar levels.

So why doesn’t everyone simply use curcumin? Because of a major barrier: absorption. Curcumin requires enhancement to be efficiently absorbed to avoid extremely large dosages just to make sure that some of it can get into the bloodstream and go to work. One of the most successful methods of making curcumin more bioavailable is to combine it with turmeric essential oil, which not only assists in absorption, but also provides beneficial turmerones from the oil as well.

Clearly, simply addressing inflammation alone isn’t going to stop metabolic syndrome, but it may help reverse the conditions associated with it and support you as you make changes to diet, exercise, and other lifestyle habits that can get you back on track.

Abstract:

Akbari M, Lankarani KB, Tabrizi R, et al. The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019;10:649. Published 2019 Jun 12. doi:10.3389/fphar.2019.00649

Background and objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. Methods: We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Results: Eighteen articles (21 studies) that comprised a total of 1,604 individuals were finally included in the meta-analysis. Curcumin intake significantly reduced body mass index (BMI) (SMD -0.37; 95% CI, -0.61, -0.13; P < 0.01), weight (SMD -0.23; 95% CI, -0.39, -0.06; P < 0.01), waist-circumference (WC) (SMD -0.25; 95% CI, -0.44, -0.05; P = 0.01), leptin levels (SMD -0.97; 95% CI, -1.18, -0.75; P < 0.001) and increased adiponectin levels (SMD 1.05; 95% CI, 0.23, 1.87; P = 0.01). We found no significant effect of curcumin intake on hip ratio (HR) (SMD -0.17; 95% CI, -0.42, 0.08; P = 0.18). Conclusions: Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.

Here is the link to the complete article: The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Terry is happy to provide his opinion on diet and nutrition, supplements and lifestyle choices. This information is for educational purposes only. It is not meant to replace the advice of your physician and is not to be considered medical advice, diagnosis or treatment. Should you have any concerns please contact your physician directly.
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