Study Spotlight

Study Spotlight

Berberine: For More than Blood Sugar and Cholesterol


Berberine is a compound found in many botanicals that has been cited as a preventive for a variety of diseases, especially type 2 diabetes and excessive LDL cholesterol levels. However, this fairly common plant alkaloid may also have an uncommonly strong ability to stop cancer.

Due to its toxicity towards cancer cells, there is a strong possibility that you may see berberine appearing as a co-treatment for tumors in the near future.

Abstract:

Ortiz LM, Lombardi P, Tillhon M, Scovassi AI. Berberine, an epiphany against cancer. Molecules. 2014 Aug 15;19(8):12349-67.

Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells. Based on this evidence, many derivatives have been synthesized to improve berberine efficiency and selectivity; the results so far obtained on human cancer cell lines support the idea that they could be promising agents for cancer treatment. The main properties of berberine and derivatives will be illustrated.

Link to complete article: Berberine, an Epiphany Against Cancer

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