Andrographis Foils the Flu : Terry Talks Nutrition

Study Spotlight

Study Spotlight

Andrographis Foils the Flu


The Ayurvedic adaptogen Andrographis paniculata isn’t the most popular herb in America yet, but chances are, it will be soon.

That’s because andrographis is one of the best immune-enhancing botanicals available. Clinical studies have shown that it shortens the duration and severity of upper respiratory tract infections and other illnesses.

In this study, researchers found that one of the plant’s key compounds, andrographolide, appears to interfere with the H1N1 virus from establishing a foothold in the body by inhibiting an enzyme that is required for them to replicate.

This illustrates just one of the powerful abilities that botanical medicines can have in strengthening the body’s immune resistance.

Abstract:

Seniya C, Shrivastava S, Singh SK, Khan GJ. Analyzing the interaction of a herbal compound Andrographolide from Andrographis paniculata as a folklore against swine flu (H1N1). Asian Pac J Trop Dis. 2014;4:S624–S630.

Objective: To find new bioactive molecules for the treatment of swine flu.

Methods: The present study is an attempt to elucidate inhibition potential of andrographolide and its derivatives along with an associated binding mechanism through virtual screening and molecular docking simulation studies.

Results: Our findings revealed structural conformation changes in 150 loop, secondary sialic acid binding site residues of ACZ97474 {Neuraminidase (A/Blore/NIV236/2009(H1N1)}. Andrographolide have been identified as the highest binging energy of -10.88 Kcal/mol, 3 hydrogen bond interactions (Arg152, Lys150, and Gly197), total intermolecular energy of -12.07 Kcal/mol with bioactivity value (Ki) of 10.59 nmol/L, while the Food and Drug Administration approved drug Oseltamivir and Zanamivir have shown 2 and 4 hydrogen bond interactions with binding energies of -6.28 Kcal/mol and -7.73Kcal/mol, respectively, which is higher than andrographolide. The guanidine group of Arg152 has binding affinities to the hydrophilic nature of the inhibitors (-OH and =O groups), as identified by docking of andrographolide (CID: 5318517) on neuraminidase.

Conclusions: Hence, andrographolide has the potential to inhibit neuraminidase activity of H1N1 and may be used as an alternative medicinal therapy for swine flu positive patient. With potent antiviral activity and a potentially new mechanism of action, andrographolide may warrant further evaluation as a possible therapy for influenza.

Here is the link to the complete article: Analyzing the interaction of a herbal compound Andrographolide from Andrographis paniculata as a folklore against swine flu (H1N1)

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