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I have the gene mutation (MTHFR) where I need to take B vitamins that are in the active form.

Q. Dear Terry, “I have the gene mutation (MTHFR) where I need to take B vitamins that are in the active form. I tried shopping for a B complex, but I don’t know what forms are “active.” Can you help?” – Gabriella S., San Juan, Puerto Rico

A. Dear Gabriella, Many people obtain B vitamins from their diet or supplements, but often times they are not in the proper form. There are estimates that 30-50% of the population has difficulty converting B-vitamins into their active form due to genetic mutations.

B vitamins are crucial to our overall health and wellbeing. They play a role in virtually every system in our body, including: cardiovascular, nervous, muscular, endocrine, digestive, and others. B vitamins are very important for cardiovascular health and help to reduce homocysteine levels and inflammation. Our nervous system also relies upon B vitamins for protecting our nerve endings, which ensures proper communication throughout our brain and body. B vitamins have been shown to be helpful with many mood conditions, like depression. Several B vitamins also play a very important role in overall energy production in our body.

Unfortunately, many medications can deplete the body of B vitamins like birth control pills, Metformin (used for type 2 diabetes), epilepsy, blood pressure and ulcer medications, steroids, and antibiotics. Even over-the-counter pain relievers like ibuprofen are at fault.

This is why I recommend taking B6, B12, and folic acid in their active forms – P-5-P (pyridoxal-5-phosphate), methylcobalamin, and methylfolate, respectively. These forms don’t require conversion by the liver, so they can go to work immediately to increase energy levels, support heart health, and optimize metabolism.

I would take active B vitamins once or twice per day.

Healthy Regards!

Terry . . . Naturally

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Terry is happy to provide his opinion on diet and nutrition, supplements and lifestyle choices. This information is for educational purposes only. It is not meant to replace the advice of your physician and is not to be considered medical advice, diagnosis or treatment. Should you have any concerns please contact your physician directly.
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