Osteoarthritis (OA) is a leading cause of physical disability and impaired quality of life. Current medical treatments to manage the condition remain symptomatic, designed to control pain and improve function and quality of life. Given the efficacy, safety and tolerability issues associated with NSAIDs, development of new agents to manage OA without adverse events remains a priority. Traditional medicines using plantderived compounds offer a safer alternative tool for the management of many chronic diseases. One such treatment option for osteoarthritis of the knee is a combination of the active principles of Boswellia serrata and the common spice Curcuma longa (turmeric).