In a placebo-controlled study involving 6 aged beagles (>8 years) who were treated with 80 mg/d atorvastatin (a statin drug) for 14.5 months, serum coenzyme Q10 levels were found to be lower in statin-treated drugs, as compared to those treated with a placebo. Moreover poorer cognition was found to be associated with lower levels of coenzyme Q10 in the lower parietal cortex. The authors conclude, “CoQ10 levels in brain may [be] linked to impaired cognition in response to atorvastatin, in agreement with previous reports that statins may have a negative impact on cognition in the elderly.”
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