This study sought to examine associations between 25-hydroxyvitamin D [25(OH)D] concentrations and cardiovascular disease (CVD), cancer, and all-cause mortality in postmenopausal women. 2,429 postmenopausal women, with 25(OH)D concentrations measured at baseline, were followed for 10 y for death from CVD, cancer, and all-cause mortality. Proportional hazards models were performed to evaluate quartiles of month-adjusted 25(OH)D concentrations, with adjustment for potential confounders. The effects of central adiposity were evaluated on the association of low 25(OH)D with all-cause mortality. Of the 2,429 women, 224 deaths occurred, with 79 deaths from CVD and 62 deaths from cancer. Multivariate-adjusted HRs that compared quartiles 1 (lowest) to 4 (highest) of 25(OH)D for all-cause mortality (HR: 1.25), CVD mortality (HR: 1.27), and cancer mortality (HR: 1.39) were not significant. There was a potential interaction between abdominal obesity and low 25(OH)D concentrations that s howed an increased risk of the lowest quartile of 25(OH)D concentrations (HR: 1.85) with increased mortality in women with a normal waist circumference but no increased risk in women with abdominal obesity (HR: 0.96). These results suggest that body fat distribution may play an important role in the modulation of the effect of low vitamin D concentrations on health.
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