In a study involving 13 normospermic male partners from infertile relationships and 15 fertile volunteers, lycopene supplementation was found to be associated with improvements in fertility. Subjects received 20 mg of lycopene or a placebo for a period of 12-weeks, followed by crossover and treatment for another 12 weeks. sRAGE levels in seminal plasma in fertile volunteers (controls) as well as in male partners in the infertile relationships group decreased. No significant effect of lycopene on sRAGE in blood plasma was found in either group, but seminal plasma sRAGE was significantly suppressed. Lycopene decreased sRAGE in seminal, but not in blood plasma. Researchers suggest decreased sRAGE may be caused by lycopene suppression of oxidative stressors and explain in part the putative improvement in fertility reported after lycopene treatment.
Click here to visit the journal website. Subscription required to view the full text of the article.