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Science Corner

Co-enzyme Q10 and L-Carnitine May Be Highly Effective in Treatment of Cyclic Vomiting Syndrome

In a retrospective chart review of the 42 cyclic vomiting syndrome (CVS) patients (from 3 to 26 years of age; median: 12 years) seen by the author over a two-year period from 2006-8, treatment with coenzyme Q10 and L-carnitine, with the addition of amitriptyline (or cyproheptadine in subjects under 5 years of age), coupled with fasting avoidance, was found to be highly effective in reducing incidences of cyclic vomiting. The age of the onset of vomiting episodes was 1 week to 15 years, with a median of 4 years. The female:male ratio was 2.2:1 (29 females and 13 males). Vomiting episodes resolved in approximately 55% of the cases, with a 75% reduction in an additional 10% of cases. The researcher’s data suggests that a protocol consisting of mitochondrial-targeted cofactors (co-enzyme Q10 and L-carnitine) plus amitriptyline (or possibly cyproheptadine in preschoolers) coupled with fasting avoidance and blood level monitoring is highly effective in the prevention of vom iting episodes. A prospective blinded clinical trial is needed.

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