In a study involving a spectrum prostate cancer cells, whole ginger extract (GE) was found to exert significant growth-inhibitory and death-inductory effects. Specifically, daily oral feeding of 100 mg/kg body weight of GE was found to inhibit growth and progression of PC-3 xenografts by approximately 56% in nude mice. Furthermore, tumor tissue from the GE-treated mice was found to have reduced proliferation index and widespread apoptosis, as compared to controls. Treatment with ginger extract was not found to exert any toxic effects in normal, rapidly dividing tissues such as found in the gut and bone marrow. The authors conclude, “To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.”
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