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In a randomized, double-blind, placebo-controlled study involving 4,447 French subjects between the ages of 45 and 60 years, daily supplementation with the antioxidants (120 mg/d vitamin C, 6 mg/c beta-carotene, 30 mg/d vitamin E, 100 microg/d selenium, 20 mg/d zinc) was found to be associated with better episodic memory scores (mean difference: 0.61), and with better verbal memory in nonsmoking subjects and those with low serum vitamin C concentrations at baseline. These results support the idea that antioxidants may help preserve aspects of cognitive function.
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