St. John’s Wort (Hypericum perforatum L.) is a useful medication in the treatment of mild to moderate depression. By reanalysis of the data obtained from a total of 154 patients, who responded in a randomised, multicentric, double-blind, placebo-controlled study, to …
Uncaria tomentosa (“uña de gato”; “cat’s claw”), a woody vine native to the Amazon rainforest, is commonly used in South American traditional medicine to treat a broad spectrum of diseases. Although recent studies have reported anti-inflammatory and anti-proliferative properties of …
In a randomized, 2-by-2 factorial design, double-blind, placebo-controlled study involving 92 adults (mean age: 57 years; mean BMI: 32 kg/m(2)), the effects of supplementation with vitamin D3 (cholecalciferol, 2000 IU/d) or calcium carbonate (400 mg, twice/day) for a period of …
The hepatoprotective effect of birch bark extract (BBE) in patients with chronic hepatitis C (CHC) was studied. Forty-two patients with serologically confirmed chronic hepatitis C were treated for 12 weeks with 160mg standardized BBE per day. The primary outcome parameter …
The anti-influenza A/PR/8/34 virus activity of silymarin was evaluated in MDCK cells and investigated the effect of silymarin on synthesis of viral mRNAs. Silymarin was investigated for its antiviral activity against influenza A/PR virus using a cytopathic effect (CPE) reduction …
The seeds of Griffonia simplicifolia Baill., a tropical shrub native to West Africa, are rich in 5-hydroxy-l-tryptophan (5-HTP), a direct precursor in the synthesis of serotonin (5-HT). In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in …
In a study involving 34 patients with nasal polyposis, oral supplementation with vitamins A, C, E, and selenium, along with intranasal steroid treatment was found to be associated with significantly lower tissue malondialdehyde levels, a marker of oxidative stress, and …
In a study involving 415 subjects with cutaneous squamous cell carcinoma and 415 controls, supplementation with grape seed extract was found to be associated with a significantly reduced risk of cutaneous squamous cell carcinoma (adjusted odds ratio=0.26), and multivitamin supplementation …
In a study involving 391 subjects with breast cancer and 782 controls, vitamin B6 intake was found to be associated with a reduction in risk of breast cancer. Specifically, women in the second and highest tertiles of vitamin B6 intake …
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors are associated with an increased risk of atrial fibrillation or flutter, according to the results of a new population-based, case-control study . The study adds evidence that these arrhythmic risks should …
Despite the fact that nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated among patients with established cardiovascular disease, many receive NSAID treatment for a short period of time. However, little is known about the association between NSAID treatment duration and risk of …
Researchers assessed whether salmon (rich in omega-3 long-chain polyunsaturated fatty acids) consumption twice a week during pregnancy would have an impact on their offspring’s umbilical vein endothelial cells (ECs) cell adhesion molecule (CAM) expression. Subjects were randomly assigned to maintain …
Study authors evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults, in a pilot, double-blind, randomized, placebo-controlled study. 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15 or 30 g short chain …
This study sought to examine associations between 25-hydroxyvitamin D concentrations and cardiovascular disease (CVD), cancer, and all-cause mortality in postmenopausal women. 2,429 postmenopausal women, with 25(OH)D concentrations measured at baseline, were followed for 10 y for death from CVD, …
Previous animal and in vivo studies have shown that Yerba mate (Ilex paraguariensis) has beneficial properties on glucose and lipid metabolism. The purpose of the present trial was to assess whether consuming roasted mate tea improves glucose and lipid profiles …
It has been hypothesized that vitamin D may have a protective effect against seasonal flu and other respiratory infections. The objective of the present observational study is to assess whether vitamin D status is associated with respiratory health or lung …
In a study involving hemodialysis patients, ALA supplementation significantly reduced inflammation markers, a risk factor for cardiovascular disease. Researchers in Iran examined the effects of alpha-lipoic acid (ALA) supplementation on inflammation, oxidative stress, and serum lipid profile levels in HD …
Researchers investigated sunlight exposure and sun sensitivity in relation to disability progression in multiple sclerosis (MS) via surveys among persons with MS in Belgium, and stratified data according to relapsing-onset and progressive-onset MS. Study authors used Kaplan-Meier survival and Cox …
Researchers conducted an observational study based on anonymous questionnaires to determine the association between green tea consumption and the incidence of influenza infection (confirmed by antigen test) among schoolchildren between the ages of 6 and 13 years. Surveys were undertaken …
Researchers enrolled fifty PHN patients for at least 3 months and fifty healthy controls. Nine circulating nutrients including ionized Ca, Zn, retinol, folic acid, vitamin B12, vitamin C, alpha-tocopherol, gamma-tocopherol and lycopene associated with both immunity and the modulation of …
In a study involving 13 normospermic male partners from infertile relationships and 15 fertile volunteers, lycopene supplementation was found to be associated with improvements in fertility. Subjects received 20 mg of lycopene or a placebo for a period of 12-weeks, …
In this study, researchers investigated the efficacy of vitamins C and E in reducing the occurrence of Upper Respiratory Tract Disease. In a population-based cohort study conducted in Sweden via web questionnaire, 1509 men and women, ages 20 to 60, …
Plasma vitamin C concentration was positively correlated with better strength, balance and overall fitness in a study involving 655 elderly Japanese women in their seventies. Researchers in Tokyo examined anthropometric measurements, physical performance, lifestyles, and plasma vitamin C concentrations of …
Folic acid during pregnancy may benefit neural development of infants and reduce the risk of neural tube defects. However, long-term effects are less clear. This study aimed at determining the impact of folic acid supplementation in mothers on language development …
Greater consumption of fruits and vegetables in healthy, active adults correlated with reduced oxidative stress markers in this cross-sectional study. Researchers enrolled 246 healthy subjects (88 men and 158 women), with a mean age of 22 years (+/- 3 y) …
In a retrospective chart review of the 42 cyclic vomiting syndrome (CVS) patients (from 3 to 26 years of age; median: 12 years) seen by the author over a two-year period from 2006-8, treatment with coenzyme Q10 and L-carnitine, with …
Researchers investigated the effect of vitamin B(5) (pantethine) on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in low to moderate cardiovascular disease (CVD) risk North American subjects. A total of 120 subjects initiated a therapeutic lifestyle change (TLC) diet …
In this meta-analysis, researchers found that omega-3 supplementation may help promote relief from bipolar depression, while no such effect was found for attenuating mania in patients with bipolar disorder. Findings were taken from clinical trials over several databases, including randomized …
In this study, the authors examined the effects of alpha-lipoic acid (ALA) supplementation on inflammation, oxidative stress, and serum lipid profile levels in hemodialysis (HD) patients in a randomized, double-blinded, placebo-controlled clinical trial. Participants included 63 patients with end-stage renal …
Probiotics combined with prebiotics may be superior to prebiotics alone in treating childhood atopic dermatitis (AD). In this randomized, double-blind clinical trial, researchers assigned 60 children (2-14 y) with moderate to severe atopic dermatitis (SCOREAD > 25) to receive Lactobacillus …
In a study involving a spectrum prostate cancer cells, whole ginger extract (GE) was found to exert significant growth-inhibitory and death-inductory effects. Specifically, daily oral feeding of 100 mg/kg body weight of GE was found to inhibit growth and progression …
In a study involving 18 patients with chemotherapy-induced peripheral neuropathy, treatment with acupuncture (6 weekly sessions) was found to significantly improve symptoms in 82% of patients. Furthermore, in addition to a reduction in symptoms, some patients reported reduced use of …
In a Cochrane systematic review of placebo-controlled randomized trials assessing the effect of vitamin D (vitamin D3, vitamin D2 or an active form of vitamin D, calcitriol) at any dose, duration, and route of administration on prevention of mortality, 50 …
In a study involving 35,897 women in the Danish National Birth Cohort, supplementation with multivitamins during a 12-week periconceptional period was found to be associated with a reduced risk of small-for-gestational-age births and preterm births in non-overweight women. Specifically, in …
In a randomized, double-blind, placebo-controlled study involving 4,447 French subjects between the ages of 45 and 60 years, daily supplementation with the antioxidants (120 mg/d vitamin C, 6 mg/c beta-carotene, 30 mg/d vitamin E, 100 microg/d selenium, 20 mg/d zinc) …
In a population-based, case-control study involving 380 cases and 719 controls in a northern region of Italy, an inverse association was found between dietary vitamin D and melanoma risk according to both crude and adjusted analyses, with the strongest associations …
In a placebo-controlled, crossover study involving 60 asthmatic children between the ages of 7 and 10 years, administration of 0.2 g/d vitamin C for a period of 6 weeks was found to exert beneficial effects in certain sub-groups of children, …
In this study involving mice, the authors demonstrate the effects of the probiotic, Lactobacillus rhamnosus on various brain regions, specifically, treatment with L. rhamnosus was found to induce region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical …
The aim of this study was to evaluate the effect of Lactobacillus rhamnosus IMC 501 and Lactobacillus paracasei IMC 502 on oxidative stress in athletes during a four-week period of intense physical activity. Two groups of twelve subjects each were …
In a study involving a prospective cohort of 6,809 pregnant women, folic acid supplementation during pregnancy was found to protect against depression 21 months post-partum (while no significant effect was found on risk of depression during pregnancy and up to …
In a study involving data collected from 35,794 mothers of participants of the Nurses’ Health Study II, inquiring about their diet during pregnancy with their nurse daughters, out of whom 199 of the nurses were diagnosed with multiple sclerosis (MS), …
In a randomized, double-blind, controlled study involving pregnant women and their infants (n=834), supplementation with DHA during pregnancy (400 mg/d from 18-22 weeks gestation through parturition) was found to reduce the occurrence of colds in offspring at 1 month and …
In a study involving an examination of data collected from 525,488 individuals between the ages of 50 and 71 years, who were followed up with for a mean 9.1 year, including 8.5 years post folic acid fortification, during which time …
In a systematic review examining evidence related to the relationship between vitamin D and the risk of falls, the authors identified 26 eligible trials of moderate quality that included data from 45,782 subjects (majority elderly and female), and found that …
In this systematic review, the authors analyzed results from 13 placebo-controlled trials examining the effects of zinc lozenges on the duration of the common cold, and they found a 42% reduction in the duration of the common cold associated with …
The anti-influenza A/PR/8/34 virus activity of silymarin was evaluated in MDCK cells and investigated the effect of silymarin on synthesis of viral mRNAs. Silymarin was investigated for its antiviral activity against influenza A/PR virus using a cytopathic effect (CPE) reduction …
The hepatoprotective effect of birch bark extract (BBE) in patients with chronic hepatitis C (CHC) was studied. Forty-two patients with serologically confirmed chronic hepatitis C were treated for 12 weeks with 160mg standardized BBE per day. The primary outcome parameter …
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors are associated with an increased risk of atrial fibrillation or flutter, according to the results of a new population-based, case-control study . The study adds evidence that these arrhythmic risks should …
The seeds of Griffonia simplicifolia Baill., a tropical shrub native to West Africa, are rich in 5-hydroxy-l-tryptophan (5-HTP), a direct precursor in the synthesis of serotonin (5-HT). In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in …
The only saponin drug currently prescribed in any significant amount in monotherapy medicines is ivy. This post-marketing surveillance study (PMSS) aimed at investigating the tolerability and safety of film-coated tablets containing ivy leaves dry extract (extracting medium: ethanol 30%, DER …
To critically assess the current evidence from randomized clinical trials (RCTs) for or against the effectiveness or efficacy of Rhodiola rosea. Systematic literature searches were performed in six electronic databases: AMED (1985-July 2009), CINAHL (1982-July 2009), The Cochrane Library (search …
This study aimed to determine the effects of chronic (15 consecutive days of treatment) per os administration of Melissa officinalis L. extract (Cyracos, Naturex) on anxiety-like reactivity in mice. As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid …
To examine the efficacy of a hop extract (standardized at 100mug 8-prenylnaringenin per day) for relief of menopausal discomforts, a 16-week randomized, double-blind, placebo-controlled, cross-over study was conducted with 36 menopausal women. The participants were randomly allocated to either placebo …
A double-blind, randomized, parallel and active-controlled clinical study was conducted to evaluate the anti-hypertensive effect as well as the tolerability of Olive leaf extract in comparison with Captopril in patients with stage-1 hypertension. Additionally, this study also investigated the hypolipidemic …
A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the potential underlying mechanisms of action …
This study determined the in vitro inhibitory effects of cocoa extracts and procyanidins against pancreatic α-amylase (PA), pancreatic lipase (PL), and secreted phospholipase A(2) (PLA(2)) and characterized the kinetics of such inhibition. Lavado, regular, and Dutch-processed cocoa extracts as well …
St. John’s Wort (Hypericum perforatum L.) is a useful medication in the treatment of mild to moderate depression. By reanalysis of the data obtained from a total of 154 patients, who responded in a randomised, multicentric, double-blind, placebo-controlled study, to …
Uncaria tomentosa (“uña de gato”; “cat’s claw”), a woody vine native to the Amazon rainforest, is commonly used in South American traditional medicine to treat a broad spectrum of diseases. Although recent studies have reported anti-inflammatory and anti-proliferative properties of …
Thyroid cancer is a cancer that forms in the thyroid gland (an organ at the base of the throat that makes hormones that help control heart rate, blood pressure, body temperature, and weight). The four main types of thyroid cancer …
Diabetes mellitus is a chronic condition in which the body does not produce or does not use insulin effectively. It is not simply hyperglycemia, or too much glucose (sugar) in the blood. Ninety percent of individuals with diabetes have type …
Macular degeneration is a major cause of gradual, painless, central vision loss in the elderly. The average age at onset of visual loss is about 75 years. After the age of 50 years, the incidence steadily increases; over one-third of …
Curcumin (CM), a well-known dietary pigment derived from Curcuma longa L., possess anticancer activities against a variety of tumors including human breast carcinoma. In combination with docetaxel, CM has been used in breast cancer management in the clinic. In order …
Throughout life, bone is constantly rebuilding itself. Bone serves as a storehouse for minerals, chiefly calcium, which can be tapped to meet the body’s mineral requirements. Bone is broken down through a process called “resorption,” releasing its minerals into the …
A study published in Stroke shows that diets rich in antioxidants from fruits, vegetables, and whole grains may lower stroke risk for women. The study included 31,035 women, ages 49–83, without heart disease and 5,680 women with a history of …