In a six-month, double-blind, placebo-controlled study involving 24 subjects, of which 12 received fluoxetine (10-20 mg/d) plus vitamin C (1000 mg/d) and 12 served as a control group and received fluoxetine plus a placebo, both for a period of 6 …
In a study involving 7664 adult participants free of known cardiovascular disease, who were followed up with for a median of 10.5 years, during which time 462 fatal and nonfatal IHD events occurred, low urinary magnesium excretion was found to …
In a study involving 4,162 young adult subjects between the ages of 18 and 30 years, with a history of asthma at baseline, who were followed up with for 20 years, during which time 446 incident cases of asthma were …
In a study involving 564 subjects with a high risk of cardiovascular disease, adherence to a Mediterranean diet for one year was found to increase plasma total antioxidant capacity levels in subjects at high risk of cardiovascular disease, and the …
In a nested case-control study involving 988 cases and 988 controls, risk of colorectal cancer was increased when plasma homocysteine levels were high (multivariate ORs for CRC were 1.46 for the highest vs the slowest quartiles of Hcy), while risk …
In a six-week, randomized, controlled trial (with a 4-week follow-up) involving 160 patients with major depressive disorder, treatment with acupuncture (28 sessions of manual acupuncture or electroacupuncture) added to paroxetine treatment was found to be associated with a significantly greater …
In a cell culture study, curcumin (active agent found in the popular yellow-colored curry spice, turmeric) was found to suppress the coactivator protein p300 (which are elevated in development and progression of prostate cancer) and CBP occupancy at sites of …
In a study involving 171 post-menopausal osteopenic women, supplementation with green tea polyphenols and a regimen of Tai Chi for 6 months was found to be associated with increased bone formation biomarkers and improved bone turnover rate, as well as …
Study authors conducted a 22-week crossover trial examining the efficacy and safety of a commercial green coffee extract product (GCA(TM)) at reducing weight and body mass. Subjects (n=16) received high-dose GCA (1050 mg), low-dose GCA (700 mg), or placebo in …
In a recent cross-sectional study involving 39 omnivores, restricting intakes of meat, fish, and poultry were found to be associated with improvements in mood. Subjects were randomly assigned to one of three groups: 1) consuming meat, fish, and poultry daily; …
In this 4-week, open-label study, the authors investigated the ability of resveratrol to influence glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT). Subjects (n=10) (72 +/- 3 yrs) (M +/- SD) with IGT were enrolled. …
The effects of fish oil, exercise and fish oil and exercise in combination on fasting and postprandial chylomicron metabolism were tested in this single blind study. Men (n=29) with metabolic syndrome were randomly assigned to take fish oil or placebo …
In a placebo-controlled study involving 109 postmenopausal women aged 40 years or older, supplementation with red clover isoflavones (80 mg/d) for a period of 90 days, was found to be associated with reducing daily hot flashes and vasomotor symptoms and …
In a crossover, placebo-controlled study involving 109 postmenopausal women, supplementation with red clover extract isoflavones was found to improve scalp hair and skin status, libido, mood, sleep, and reduce tiredness. Subjects were randomized to: 2 daily capsules of the red …
In this double-blind, randomized, placebo-controlled, intervention study involving 103 postmenopausal women, supplementation with green tea catechins (EGCG as polyphenon E) for a period of 2 months was found to significantly reduce LDL cholesterol concentrations and glucose-related markers. Subjects were randomized …
Researchers investigated the effect of high-antioxidant potatoes on hypertension. In a single-dose study, 6-8 microwaved potatoes with skins or a comparable amount of refined starch as cooked biscuits were given to normal fasting subjects (n=8), and repeated samples of blood …
In a study involving 10 patients with fibromyalgia, levels of coenzyme Q10 in salivary cells and mononuclear blood cells were reduced. Supplementation with 300 mg/d coenzyme Q10 was found to be associated with and improvement in clinical symptoms and a …
The effects of sesame seeds on reducing serum lipids and enhancing antioxidant capacity were researched in this study. Hyperlipidemic patients (n=38) were divided into two groups (treatment group received 40 g white sesame seeds daily, with 240 kcal was removed …
Researchers examined whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance in this cross-sectional and longitudinal study. Subjects were 65 yrs or older. Blood was collected in 1995/1996 (n=1352). Physical performance was …
In this systematic review and meta-analysis investigating the effects of chocolate, cocoa, and flavan-3-ols on major cardiovascular disease (CVD) risk factors, data from 42 studies including acute or short-term chronic (<=18 wk) randomized controlled trials (RCTs) of chocolate, cocoa, or …
In this systematic review and meta-analysis investigating the effects of chocolate, cocoa, and flavan-3-ols on major cardiovascular disease (CVD) risk factors, data from 42 studies including acute or short-term chronic (<=18 wk) randomized controlled trials (RCTs) of chocolate, cocoa, or …
Researchers examined whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance in this cross-sectional and longitudinal study. Subjects were 65 yrs or older. Blood was collected in 1995/1996 (n=1352). Physical performance was …
Researchers conducted a double-blind, randomized, placebo-controlled intervention study to investigate the effects of green tea on circulating hormone levels, an established breast cancer risk factor. The effect of the main green tea catechin, epigallocatechin gallate (EGCG), taken in a green …
In a study involving 16 adolescent patients hospitalized for anorexia nervosa, decreased concentration of coenzyme Q10 in platelets was found at the time of admission to the hospital, which may suggest mitochondrial depletion. Subjects stayed in the hospital for 12 …
Researchers investigated the effect of curcumin (20, 40 and 80mg/kg; p.o.) in alcohol-induced neuropathy in rats. Ethanol (35% v/v, 10g/kg; p.o.) was administered for 10 weeks, significantly decreasing thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia and nerve conduction velocity and causing …
Study authors investigated whether regular consumption of gold kiwifruit will reduce symptoms of URTI in older people, and determined the effect it has on plasma antioxidants, and markers of oxidative stress, inflammation and immune function. Participants (n=32)( >= 65 years) …
In this study, researchers investigated the relationships between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. Pregnant women (n = 628) were recruited in the last trimester of pregnancy. Folate status determined by …
In this double-blind, placebo-controlled, randomized, multicenter pilot study, researchers investigated the effects of the polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA) 460 mg and eicosapentaenoic acid (EPA) 380 mg, on hypertriglyceridemia in HIV-treated patients. Subjects (n=48) were male HIV-infected patients …
Researchers examined the relationship between intestinal microbial diversity and development of atopic eczema in the first year of life. Subjects were infants (n=40) with IgE-associated eczema (n=20) (IAE) and without any allergic manifestation (n=20) (NA) until 2 years of age. …
Study authors examined the cross-sectional relationship between nutrient status (30 plasma biomarkers of diet) and indices of brain health (cognitive and MRI outcomes) in dementia-free elders (mean age=87, 62% female). Two NBPs associated with more favorable cognitive and MRI measures: …
In a systematic review and meta-analysis of studies analyzing the association between maternal total Homocysteine (tHcy) status and newborn birth weight, the authors found a small increased risk of small-for-gestational-age (SGA) newborns (which has been associated with increased risks of …
A study published in The Journal of Nutrition shows that a diet rich in slowly digested carbohydrates, such as whole grains, legumes, and other high-fiber foods, may reduce markers of inflammation associated with chronic disease. The controlled, randomized feeding study, …
A study published in Food and Function shows that the content and quality, or potency, of antioxidants present in walnuts was highest among the nuts. Free and total (after basic hydrolysis) polyphenols in nine types of raw and roasted nuts …
In a study involving data collected from 52,917 singleton live-born infants and from the deaths of 1,525 children under the age of 5 years, risk of death of children under the age of 5 was significantly reduced by 34% if …
In a controlled, six-month trial involving 57 women with polycystic ovarian syndrome (PCOS), adherence to a high protein diet (>40% of energy from protein and 30% from fat) was found to be associated with greater weight loss (mean: 4.4 kg) …
In this Cochrane review, the authors analyzed results from randomized, double-blind, placebo-controlled trials involving a total of 452 patients, that compared the effects of coenzyme Q10 to placebo in patients suffering from early and mid-stage primary Parkinson’s disease. Results found …
In this study, 2 parallel, double-blind, placebo-controlled, 16 week trials were conducted involving 171 overweight and obese subjects (mean age: 40 years) randomly assigned to either consume 240 mL of an orange juice (regular or lite) fortified with 250 mg …
In this meta-analysis of prospective cohort studies investigating the effects of vitamin D status on risk of mortality, the evidence suggest that as circulating 25(OH)D levels increase, the risk of mortality decreases in a non-linear manner, with optimal concentrations between …
In a study involving rats induced with liver injury through a single dose of acetaminophen (700 mg/kg, p.o.), administration with coenzyme Q10 (20 i.p. injections, 10 mg/kg each) at 1 and 12 hours following acetaminophen administration, was found to significantly …
In a prospective, randomized, patient-blinded study involving 182 patients, treatment with ear (auricular) acupuncture – one of the microsystems of acupuncture – was found to significantly reduce anxiety prior to dental treatment (state anxiety scores reduced from 54.7 to 46.9), …
In a prospective, population-based, cohort study involving 20,069 men and women between the ages of 20 and 65 years, free of cardiovascular disease at baseline, who were followed up with for 10 years, during which time 233 incident cases of …
In a prospective, population-based, cohort study involving analysis of data from 20,069 women and men between the ages of 20 and 65 years, free of cardiovascular diseases at baseline, who were followed up with for an average 10.3 years, during …
In this randomized trial involving 12 subjects experiencing pruritis associated with atopic dermatits, acupressure at a particular acupuncture point, performed 3 times per week for a period of 4 weeks, along with ‘standard of care’ was found to be associated …
In a study involving 93 pregnant women (after the 30th week of gestation) in Japan, out of which 10 were found to have severe vitamin D deficiency (<10 ng/mL), and out of which 85 (89.5%) were found to have hypovitaminosis …
In a prospective, observational study involving an analysis of data from 38,954 children born before 2008 whose mothers completed a 3-year follow-up questionnaire including information about their use of folic acid supplementation in the interval from 4 weeks prior to …
In a study involving 452 children (304 overweight/obese, 148 healthy, normal weight), higher 25(OH)D(3) levels were found to be significantly associated with a reduced presence of the metabolic syndrome. Furthermore, obesity, central obesity, hypertension, hypertriglyceridemia, low HDL cholesterol, insulin resistance, …
In a cross-sectional study involving 126 apparently healthy elderly subjects (59 male, 67 female) over the age of 60 years, low plasma melatonin levels were found to correlate with age-related high frequency hearing loss. The average plasma melatonin level among …
In a retrospective, cross-sectional analysis involving 472 subjects (203 with type 1 diabetes mellitus, 116 first-degree relatives of type 1 diabetics, and 153 controls without diabetes), serum vitamin D-binding protein levels were found to be highest in the healthy controls …
In a prospective study involving an analysis of data collected from 66,227 men and women between the ages of 50 and 76 years, out of which 588 cases of hematological malignancy were identified, high use of garlic supplements, ever use …
In a study involving 2,236 women who had been diagnosed with early-stage breast cancer between 1997 and 2000, persistent multivitamin use from pre-diagnosis to post-diagnosis was associated with a decreased risk of recurrence (HR=0.76), although non-significant, and a decreased risk …
In a pilot study involving 6 patients with chemotherapy-induced peripheral neuropathy, treatment with acupuncture for a period of 10 weeks was found to be associated with marked improvements in nerve conduction studies, as compared to patients in a control group …
In this study, the authors assessed blood samples from patients with lung cancer and found that levels of malondialdehyde (MDA) and the rate of DNA damage were significantly higher, while levels of coenzyme Q10 were significantly lower in patients with …
In a study involving 140 patients with the metabolic syndrome and/or non-alcoholic fatty liver disease (NAFLD), daily supplementation with fish oil (2 g/d) for a period of 6 months was found to be associated with reductions in serum triglycerides, LDL-cholesterol, …
In a double-blind, placebo-controlled, randomized study involving 72 healthy Italian blue-collar male smokers, supplementation with the probiotic, Lactobacillus casei Shirota (LcS) for a period of 3 weeks was found to be associated with significant increases in natural killer activity, which …
Study authors compared a two-drug combination (including nutraceuticals, i.e. antioxidants) with carnitine + celecoxib +/- megestrol acetate for the treatment of cancer-related anorexia/cachexia syndrome (CACS). The primary endpoints were increase of lean body mass (LBM) and improvement of total daily …
In a study involving 20 women experiencing infertility who were undergoing ovarian stimulation for in vitro fertilization, higher levels of coenzyme Q10/protein were found to be associated with mature, as opposed to dysmorphic, oocytes, and coenzyme Q10/cholesterol was found to …
In a study involving an analysis of data from a nationally representative sample of adults with diagnosed diabetes mellitus (40 years of age or older), out of which 81% were found to have vitamin D insufficiency (less than 30 ng/ml), …
In a population-based study involving 1,639 elderly subjects (65+ years of age at baseline), serum 25-hydroxy vitamin D3 levels in the lowest sex-specific quintile were found to be associated with an average 2.1 units lower COGTEL score (assessment of cognitive …
In a prospective, randomized, parallel group, single-blind study involving 80 elderly subjects over the age of 75 years, with hypercholesterolemia, who were statin-intolerant and who refused other medications for the treatment of hypercholesterolemia, supplementation with a combination of nutraceuticals (berberine …
Meridian massage may improve infant growth and well being. The authors of this study assed the effects of meridian massage versus gentle touch massage on infant’s health and physical growth as perceived by mothers. One hundred sixty nine healthy infants …
Enteral fish oil may be an effective adjunctive treatment for infants with parenteral nutrition-associated liver disease (PNALD). In this retrospective case series, 6 infants (average age 5 +/- 2.6 weeks ) with short bowel syndrome and PNALD were treated with …
In this study, researchers found that supplementation with acetyl-L-carnitine may offer marked benefits to chronic hepatitis B patients. Sixty patients with chronic hepatitis C underwent treatment with pegylated-interferon-a 2b (Peg-IFN-a 2b) + ribavirin (RBV) (group A; n=29) or Peg-IFN-a 2b …
Treatment with acetyl-L-carnitine (ALC) showed significant improvement in cognitive function for patients with severe hepatic encephalopathy. Sixty one patients with severe hepatic encephalopathy were recruited into this randomized, double-blind, placebo-controlled study. Subjects received either 2 g ALC twice a day …
Probiotics, prebiotics and synbiotics might modify the intestinal environment and stimulate the immune system of senior citizens. The authors examined the effects of symbiotic supplementation for intestinal health of healthy elderly volunteers. Over a two week period, subjects took either …
Osteoarthritis (OA) is a leading cause of physical disability and impaired quality of life. Current medical treatments to manage the condition remain symptomatic, designed to control pain and improve function and quality of life. Given the efficacy, safety and tolerability …
Curcumin is known to possess potent antiinflammatory and antiarthritic properties. This pilot clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA). Forty-five patients diagnosed with RAwere …
In this study, researchers evaluated whether adding vitamins C and E to standard triple therapy increases the eradication rate of Helicobacter Pylori (H. Pylori). The study included 120 patients in an out-patient treatment facility exhibiting H. pylori-positive non-ulcer dyspepsia and …
Lower serum levels of vitamin C in patients with lichen planus (LP) may contribute to increased levels of free radicals, resulting in increasing oxidative damage. In this study, 30 patients with LP, who had never received treatment for their disease, …
Dairy-based probiotic consumption by primiparous women associated with lowered risk of preeclampsia. A Norwegian study analyzed data from 33,399 women who participated in the Norwegian Mother Child Cohort Study from the years 2002- 2008. The intake of milk-based products containing …
Omega-3 fatty acids intake during gestation and lactation may modify development of the newborn digestive system and have a positive correlation with a lowered risk for allergies. In this study, researchers demonstrated that supplementation of the maternal diet with a …
Researchers determined that while an optimal dosage of vitamin D(3) is not known, high doses are not more effective than standard doses in improving bone mass density (BMD) and reducing bone turnover in postmenopausal women with reduced bone mass. Vitamin …
Researchers found that a multi-nutrient supplement offered benefits to recovery, anti-inflammation and physical performance in middle aged men and women. In a study comprised of 31 active men and women with an average age of 54, volunteers were randomized to …
Researchers compared treatment with orlistat plus l-carnitine compared to orlistat alone on body weight, glycemic and lipid control, and inflammatory parameters in obese type 2 diabetic patients. The study enrolled 258 patients with uncontrolled type 2 diabetes mellitus (T2DM) who …
Vitamin D deficiency is a common problem in patients with Crohn’s disease. Researchers used a novel vitamin D bioavailability test to examine the ability of patients with quiescent Crohn’s disease (CD) to absorb vitamin D(2). Study participants were comprised of …
In a study examining the relationship between serum vitamin D and airway structure and function in 86 children, average age of 11.7 years, who were either severe, therapy resistant asthma (STRA), moderate asthmatics, or non-asthmatic controls, the authors found that …
In a study involving 46 hypertensive (31 pre-eclamptic and 15 chronic hypertensive) and 60 normotensive pregnant women, total antioxidant capacity and sulphydryl concentrations were significantly lower (in maternal blood plasma, cord blood plasma, maternal milk) in the hypertensive women, and …
In a study involving 450 pregnant women scheduled for elective cesarean section delivery, treatment with acupuncture (with electrical stimulation on the acupuncture point PC-6, bilaterally) for 30 minutes prior to spinal anesthesia was found to be as effective as treatment …
In a randomized study involving 40 overweight and obese adults with the metabolic syndrome, consumption of adequate dairy (3.5 servings/day) was found to be associated with decreases in malondialdehyde by 35% and oxidized LDL by 11% at 7 days, with …
Curcumin is known to possess potent antiinflammatory and antiarthritic properties. This pilot clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA). Forty-five patients diagnosed with RA …
In a randomized, double-blind, placebo-controlled study involving 20 healthy, male, long-distance runners, supplementation with a flavanol-rich lychee fruit extract was found to be associated with significant improvements in the change in serum interleukin-6 levels between pre- and mid-training, as well …
In a review and meta-analysis of studies investigating the effects of green tea and its extract on total cholesterol, LDL cholesterol, and HDL cholesterol, results of 14 randomized, controlled trials involving 1,136 subjects were analyzed and results showed that consumption …
In a large, population-based survey study involving cross-sectional analyses carried out on data collected from 5,787 Korean adults (2543 men and 3334 women), low serum 25(OH)D concentrations were associated with an increased risk of diabetes mellitus. Diabetes mellitus was defined …
In a study involving 4,447 French subjects between the ages of 45 and 60 years, who had previously participated in a randomized, double-blind, placebo-controlled study (1994-2002) in which they received daily supplementation with vitamin C (120 mg), beta-carotene (6 mg), …
In a placebo-controlled study involving 6 aged beagles (>8 years) who were treated with 80 mg/d atorvastatin (a statin drug) for 14.5 months, serum coenzyme Q10 levels were found to be lower in statin-treated drugs, as compared to those treated …
In this meta-analysis which included data gathered from 22 case-control studies, involving a total of 10,073 subjects, which investigated an association between vitamin or antioxidant intake (or serum level) and cervical neoplasm risk, results found that intakes of vitamin B12 …
In a prospective study involving data collected from 23,943 subjects without pre-existing cancer and myocardial infarction/stroke at baseline, who were followed for an average of 11 years, during which time 1,101 deaths were documented (cancer deaths=513; cardiovascular deaths=264), baseline users …
Curcumin (CM), a well-known dietary pigment derived from Curcuma longa L., possess anticancer activities against a variety of tumors including human breast carcinoma. In combination with docetaxel, CM has been used in breast cancer management in the clinic. In order …
The only saponin drug currently prescribed in any significant amount in monotherapy medicines is ivy. This post-marketing surveillance study (PMSS) aimed at investigating the tolerability and safety of film-coated tablets containing ivy leaves dry extract (extracting medium: ethanol 30%, DER …
St. John’s Wort (Hypericum perforatum L.) is a useful medication in the treatment of mild to moderate depression. By reanalysis of the data obtained from a total of 154 patients, who responded in a randomised, multicentric, double-blind, placebo-controlled study, to …
Uncaria tomentosa (“uña de gato”; “cat’s claw”), a woody vine native to the Amazon rainforest, is commonly used in South American traditional medicine to treat a broad spectrum of diseases. Although recent studies have reported anti-inflammatory and anti-proliferative properties of …
In a randomized, 2-by-2 factorial design, double-blind, placebo-controlled study involving 92 adults (mean age: 57 years; mean BMI: 32 kg/m(2)), the effects of supplementation with vitamin D3 (cholecalciferol, 2000 IU/d) or calcium carbonate (400 mg, twice/day) for a period of …
The hepatoprotective effect of birch bark extract (BBE) in patients with chronic hepatitis C (CHC) was studied. Forty-two patients with serologically confirmed chronic hepatitis C were treated for 12 weeks with 160mg standardized BBE per day. The primary outcome parameter …
The anti-influenza A/PR/8/34 virus activity of silymarin was evaluated in MDCK cells and investigated the effect of silymarin on synthesis of viral mRNAs. Silymarin was investigated for its antiviral activity against influenza A/PR virus using a cytopathic effect (CPE) reduction …
The seeds of Griffonia simplicifolia Baill., a tropical shrub native to West Africa, are rich in 5-hydroxy-l-tryptophan (5-HTP), a direct precursor in the synthesis of serotonin (5-HT). In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in …
In a study involving 34 patients with nasal polyposis, oral supplementation with vitamins A, C, E, and selenium, along with intranasal steroid treatment was found to be associated with significantly lower tissue malondialdehyde levels, a marker of oxidative stress, and …
In a study involving 415 subjects with cutaneous squamous cell carcinoma and 415 controls, supplementation with grape seed extract was found to be associated with a significantly reduced risk of cutaneous squamous cell carcinoma (adjusted odds ratio=0.26), and multivitamin supplementation …
In a study involving 391 subjects with breast cancer and 782 controls, vitamin B6 intake was found to be associated with a reduction in risk of breast cancer. Specifically, women in the second and highest tertiles of vitamin B6 intake …
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors are associated with an increased risk of atrial fibrillation or flutter, according to the results of a new population-based, case-control study . The study adds evidence that these arrhythmic risks should …
Despite the fact that nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated among patients with established cardiovascular disease, many receive NSAID treatment for a short period of time. However, little is known about the association between NSAID treatment duration and risk of …
Researchers assessed whether salmon (rich in omega-3 long-chain polyunsaturated fatty acids) consumption twice a week during pregnancy would have an impact on their offspring’s umbilical vein endothelial cells (ECs) cell adhesion molecule (CAM) expression. Subjects were randomly assigned to maintain …
Study authors evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults, in a pilot, double-blind, randomized, placebo-controlled study. 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15 or 30 g short chain …
This study sought to examine associations between 25-hydroxyvitamin D concentrations and cardiovascular disease (CVD), cancer, and all-cause mortality in postmenopausal women. 2,429 postmenopausal women, with 25(OH)D concentrations measured at baseline, were followed for 10 y for death from CVD, …
Previous animal and in vivo studies have shown that Yerba mate (Ilex paraguariensis) has beneficial properties on glucose and lipid metabolism. The purpose of the present trial was to assess whether consuming roasted mate tea improves glucose and lipid profiles …
It has been hypothesized that vitamin D may have a protective effect against seasonal flu and other respiratory infections. The objective of the present observational study is to assess whether vitamin D status is associated with respiratory health or lung …
In a study involving hemodialysis patients, ALA supplementation significantly reduced inflammation markers, a risk factor for cardiovascular disease. Researchers in Iran examined the effects of alpha-lipoic acid (ALA) supplementation on inflammation, oxidative stress, and serum lipid profile levels in HD …
Researchers investigated sunlight exposure and sun sensitivity in relation to disability progression in multiple sclerosis (MS) via surveys among persons with MS in Belgium, and stratified data according to relapsing-onset and progressive-onset MS. Study authors used Kaplan-Meier survival and Cox …
Researchers conducted an observational study based on anonymous questionnaires to determine the association between green tea consumption and the incidence of influenza infection (confirmed by antigen test) among schoolchildren between the ages of 6 and 13 years. Surveys were undertaken …
Researchers enrolled fifty PHN patients for at least 3 months and fifty healthy controls. Nine circulating nutrients including ionized Ca, Zn, retinol, folic acid, vitamin B12, vitamin C, alpha-tocopherol, gamma-tocopherol and lycopene associated with both immunity and the modulation of …
In a study involving 13 normospermic male partners from infertile relationships and 15 fertile volunteers, lycopene supplementation was found to be associated with improvements in fertility. Subjects received 20 mg of lycopene or a placebo for a period of 12-weeks, …
In this study, researchers investigated the efficacy of vitamins C and E in reducing the occurrence of Upper Respiratory Tract Disease. In a population-based cohort study conducted in Sweden via web questionnaire, 1509 men and women, ages 20 to 60, …
Plasma vitamin C concentration was positively correlated with better strength, balance and overall fitness in a study involving 655 elderly Japanese women in their seventies. Researchers in Tokyo examined anthropometric measurements, physical performance, lifestyles, and plasma vitamin C concentrations of …
Folic acid during pregnancy may benefit neural development of infants and reduce the risk of neural tube defects. However, long-term effects are less clear. This study aimed at determining the impact of folic acid supplementation in mothers on language development …
Greater consumption of fruits and vegetables in healthy, active adults correlated with reduced oxidative stress markers in this cross-sectional study. Researchers enrolled 246 healthy subjects (88 men and 158 women), with a mean age of 22 years (+/- 3 y) …
In a retrospective chart review of the 42 cyclic vomiting syndrome (CVS) patients (from 3 to 26 years of age; median: 12 years) seen by the author over a two-year period from 2006-8, treatment with coenzyme Q10 and L-carnitine, with …
Researchers investigated the effect of vitamin B(5) (pantethine) on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in low to moderate cardiovascular disease (CVD) risk North American subjects. A total of 120 subjects initiated a therapeutic lifestyle change (TLC) diet …
In this meta-analysis, researchers found that omega-3 supplementation may help promote relief from bipolar depression, while no such effect was found for attenuating mania in patients with bipolar disorder. Findings were taken from clinical trials over several databases, including randomized …
In this study, the authors examined the effects of alpha-lipoic acid (ALA) supplementation on inflammation, oxidative stress, and serum lipid profile levels in hemodialysis (HD) patients in a randomized, double-blinded, placebo-controlled clinical trial. Participants included 63 patients with end-stage renal …
Probiotics combined with prebiotics may be superior to prebiotics alone in treating childhood atopic dermatitis (AD). In this randomized, double-blind clinical trial, researchers assigned 60 children (2-14 y) with moderate to severe atopic dermatitis (SCOREAD > 25) to receive Lactobacillus …
In a study involving a spectrum prostate cancer cells, whole ginger extract (GE) was found to exert significant growth-inhibitory and death-inductory effects. Specifically, daily oral feeding of 100 mg/kg body weight of GE was found to inhibit growth and progression …
In a study involving 18 patients with chemotherapy-induced peripheral neuropathy, treatment with acupuncture (6 weekly sessions) was found to significantly improve symptoms in 82% of patients. Furthermore, in addition to a reduction in symptoms, some patients reported reduced use of …
In a Cochrane systematic review of placebo-controlled randomized trials assessing the effect of vitamin D (vitamin D3, vitamin D2 or an active form of vitamin D, calcitriol) at any dose, duration, and route of administration on prevention of mortality, 50 …
In a study involving 35,897 women in the Danish National Birth Cohort, supplementation with multivitamins during a 12-week periconceptional period was found to be associated with a reduced risk of small-for-gestational-age births and preterm births in non-overweight women. Specifically, in …
In a randomized, double-blind, placebo-controlled study involving 4,447 French subjects between the ages of 45 and 60 years, daily supplementation with the antioxidants (120 mg/d vitamin C, 6 mg/c beta-carotene, 30 mg/d vitamin E, 100 microg/d selenium, 20 mg/d zinc) …
In a population-based, case-control study involving 380 cases and 719 controls in a northern region of Italy, an inverse association was found between dietary vitamin D and melanoma risk according to both crude and adjusted analyses, with the strongest associations …
In a placebo-controlled, crossover study involving 60 asthmatic children between the ages of 7 and 10 years, administration of 0.2 g/d vitamin C for a period of 6 weeks was found to exert beneficial effects in certain sub-groups of children, …
In this study involving mice, the authors demonstrate the effects of the probiotic, Lactobacillus rhamnosus on various brain regions, specifically, treatment with L. rhamnosus was found to induce region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical …
The aim of this study was to evaluate the effect of Lactobacillus rhamnosus IMC 501 and Lactobacillus paracasei IMC 502 on oxidative stress in athletes during a four-week period of intense physical activity. Two groups of twelve subjects each were …
In a study involving a prospective cohort of 6,809 pregnant women, folic acid supplementation during pregnancy was found to protect against depression 21 months post-partum (while no significant effect was found on risk of depression during pregnancy and up to …
In a study involving data collected from 35,794 mothers of participants of the Nurses’ Health Study II, inquiring about their diet during pregnancy with their nurse daughters, out of whom 199 of the nurses were diagnosed with multiple sclerosis (MS), …
In a randomized, double-blind, controlled study involving pregnant women and their infants (n=834), supplementation with DHA during pregnancy (400 mg/d from 18-22 weeks gestation through parturition) was found to reduce the occurrence of colds in offspring at 1 month and …
In a study involving an examination of data collected from 525,488 individuals between the ages of 50 and 71 years, who were followed up with for a mean 9.1 year, including 8.5 years post folic acid fortification, during which time …
In a systematic review examining evidence related to the relationship between vitamin D and the risk of falls, the authors identified 26 eligible trials of moderate quality that included data from 45,782 subjects (majority elderly and female), and found that …
In this systematic review, the authors analyzed results from 13 placebo-controlled trials examining the effects of zinc lozenges on the duration of the common cold, and they found a 42% reduction in the duration of the common cold associated with …
The anti-influenza A/PR/8/34 virus activity of silymarin was evaluated in MDCK cells and investigated the effect of silymarin on synthesis of viral mRNAs. Silymarin was investigated for its antiviral activity against influenza A/PR virus using a cytopathic effect (CPE) reduction …
The hepatoprotective effect of birch bark extract (BBE) in patients with chronic hepatitis C (CHC) was studied. Forty-two patients with serologically confirmed chronic hepatitis C were treated for 12 weeks with 160mg standardized BBE per day. The primary outcome parameter …
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors are associated with an increased risk of atrial fibrillation or flutter, according to the results of a new population-based, case-control study . The study adds evidence that these arrhythmic risks should …
The seeds of Griffonia simplicifolia Baill., a tropical shrub native to West Africa, are rich in 5-hydroxy-l-tryptophan (5-HTP), a direct precursor in the synthesis of serotonin (5-HT). In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in …
The only saponin drug currently prescribed in any significant amount in monotherapy medicines is ivy. This post-marketing surveillance study (PMSS) aimed at investigating the tolerability and safety of film-coated tablets containing ivy leaves dry extract (extracting medium: ethanol 30%, DER …
To critically assess the current evidence from randomized clinical trials (RCTs) for or against the effectiveness or efficacy of Rhodiola rosea. Systematic literature searches were performed in six electronic databases: AMED (1985-July 2009), CINAHL (1982-July 2009), The Cochrane Library (search …
This study aimed to determine the effects of chronic (15 consecutive days of treatment) per os administration of Melissa officinalis L. extract (Cyracos, Naturex) on anxiety-like reactivity in mice. As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid …
To examine the efficacy of a hop extract (standardized at 100mug 8-prenylnaringenin per day) for relief of menopausal discomforts, a 16-week randomized, double-blind, placebo-controlled, cross-over study was conducted with 36 menopausal women. The participants were randomly allocated to either placebo …
A double-blind, randomized, parallel and active-controlled clinical study was conducted to evaluate the anti-hypertensive effect as well as the tolerability of Olive leaf extract in comparison with Captopril in patients with stage-1 hypertension. Additionally, this study also investigated the hypolipidemic …
A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the potential underlying mechanisms of action …
This study determined the in vitro inhibitory effects of cocoa extracts and procyanidins against pancreatic α-amylase (PA), pancreatic lipase (PL), and secreted phospholipase A(2) (PLA(2)) and characterized the kinetics of such inhibition. Lavado, regular, and Dutch-processed cocoa extracts as well …
St. John’s Wort (Hypericum perforatum L.) is a useful medication in the treatment of mild to moderate depression. By reanalysis of the data obtained from a total of 154 patients, who responded in a randomised, multicentric, double-blind, placebo-controlled study, to …
Uncaria tomentosa (“uña de gato”; “cat’s claw”), a woody vine native to the Amazon rainforest, is commonly used in South American traditional medicine to treat a broad spectrum of diseases. Although recent studies have reported anti-inflammatory and anti-proliferative properties of …
Thyroid cancer is a cancer that forms in the thyroid gland (an organ at the base of the throat that makes hormones that help control heart rate, blood pressure, body temperature, and weight). The four main types of thyroid cancer …
Diabetes mellitus is a chronic condition in which the body does not produce or does not use insulin effectively. It is not simply hyperglycemia, or too much glucose (sugar) in the blood. Ninety percent of individuals with diabetes have type …
Macular degeneration is a major cause of gradual, painless, central vision loss in the elderly. The average age at onset of visual loss is about 75 years. After the age of 50 years, the incidence steadily increases; over one-third of …
Curcumin (CM), a well-known dietary pigment derived from Curcuma longa L., possess anticancer activities against a variety of tumors including human breast carcinoma. In combination with docetaxel, CM has been used in breast cancer management in the clinic. In order …
Throughout life, bone is constantly rebuilding itself. Bone serves as a storehouse for minerals, chiefly calcium, which can be tapped to meet the body’s mineral requirements. Bone is broken down through a process called “resorption,” releasing its minerals into the …
A study published in Stroke shows that diets rich in antioxidants from fruits, vegetables, and whole grains may lower stroke risk for women. The study included 31,035 women, ages 49–83, without heart disease and 5,680 women with a history of …